a 3β-hydroxy-Δ 5 -steroid + NAD + ⇌ a 3-oxo-Δ 5 -steroid + NADH + H + Nomenclature Edit. 3β-HSD is potently inhibited by azastene, cyanoketone, epostane, and trilostane. [4] Medroxyprogesterone acetate and medrogestone are weak inhibitors of 3β-HSD which may substantially inhibit it at high dosages. Clinical significance Edit. Steroidogenic enzyme 3α-Hydroxysteroid dehydrogenase. Cheatum SG, Watten JC (1966). ”Purification and properties of doi:10.1021/bi00896a015. PMID14220672.
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