The HSD3B2 gene provides instructions for making the 3β-HSD enzyme. This enzyme is found in the gonads and adrenal glands . The 3β-HSD enzyme is involved in the production of many hormones, including cortisol , aldosterone , androgens, and estrogen. Cortisol has numerous functions such as maintaining energy and blood sugar (glucose) levels, protecting the body from stress, and suppressing inflammation. Aldosterone is sometimes called the salt-retaining hormone because it regulates the amount of salt retained by the kidney. The retention of salt affects fluid levels and blood pressure. Androgens and estrogen are essential for normal sexual development and reproduction.
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HSDs participate in the synthesis and metabolism of sex steroid hormones by catalyzing the conversion of a hydroxy group to a keto group or vice versa on a steroid ring in a specific position and orientation (Yang et al., 2005). Studies on the expression profiles of hsd genes at different stages of grouper sex reversal may provide us a better understanding on the roles of hsd genes in sex reversal. In the gonad, two ( hsd3b1 and hsd17b14 ) and eight ( hsd3b7 , hsd17b1 , hsd17b7l , hsd17b10 , hsd17b12a , hsd17b12b , hsdl1 , and hsdl2 ) β -HSD genes were up- and downregulated during sex reversal, respectively. Hsd3b1 catalyzes the second step of steroidogenesis and is required for the synthesis of all steroids including 11-KT (Hsu et al., 2009). Chain – several single bets legalização das apostas esportivas do brasil on irrelevant outcomes. Transfection of HSD17B14 in human breast cancer cells significantly decreased the levels of estradiol (Jansson et al., 2006), and further studies have suggested a role for HSD17B14 in the local inactivation of steroid (Lukacik et al., 2007). Therefore, we hypothesized that the increased expression levels of hsd3b1 during the sex reversal of grouper may promote the synthesis of 11-KT, while the increased expression level of hsd17b14 may lead to the inactivation of estradiol in this study. Conclusion. Www 11bets.
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Pinterest Facebook Twitter. Authorized object. You are not authorized for enterprise commercial use yet. happy baisakh transparent png. happy baisakh drum concept. happy baisakh transparent png. happy easter with colourfull theme. happy colourfull flash. happy new year colourfull background. colourfull Background. ©️ 2017-2023 Pngtree - All Rights Reserved. Monterrey fc ao vivo.122, 164–171. doi: 10.1016/j.jsbmb.2010.07.003.
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